The University of Alberta Discovery
Source from: DCA Research Information
March 15, 2007
Deoxycholic Acid or DCA is an odourless, colourless, inexpensive, relatively non-toxic, small molecule. And researchers at the University of Alberta believe it may soon be used as an effective treatment for many forms of cancer.
Dr. Evangelos Michelakis, a professor at the U of A Department of Medicine, has shown that dichloroacetate (DCA) causes regression in several cancers, including lung, breast, and brain tumors.
Michelakis and his colleagues, including post-doctoral fellow Dr. Sebastien Bonnet, have published the results of their research in the journal Cancer Cell.
Scientists and doctors have used DCA for decades to treat children with inborn errors of metabolism due to mitochondrial diseases. Mitochondria, the energy producing units in cells, have been connected with cancer since the 1930s, when researchers first noticed that these organelles dysfunction when cancer is present.
Until recently, researchers believed that cancer-affected mitochondria are permanently damaged and that this damage is the result, not the cause, of the cancer. But Michelakis, a cardiologist, questioned this belief and began testing DCA, which activates a critical mitochondrial enzyme, as a way to "revive" cancer-affected mitochondria.
The results astounded him. Michelakis and his colleagues found that DCA normalized the mitochondrial function in many cancers, showing that their function was actively suppressed by the cancer but was not permanently damaged by it.
More importantly, they found that the normalization of mitochondrial function resulted in a significant decrease in tumor growth both in test tubes and in animal models. Also, they noted that DCA, unlike most currently used chemotherapies, did not have any effects on normal, non-cancerous tissues.
"I think DCA can be selective for cancer because it attacks a fundamental process in cancer development that is unique to cancer cells," Michelakis said. "One of the really exciting things about this compound is that it might be able to treat many different forms of cancer".
Another encouraging thing about DCA is that, being so small, it is easily absorbed in the body, and, after oral intake, it can reach areas in the body that other drugs cannot, making it possible to treat brain cancers, for example.
Also, because DCA has been used in both healthy people and sick patients with mitochondrial diseases, researchers already know that it is a relatively non-toxic molecule that can be immediately tested patients with cancer.
"The results are intriguing because they point to the critical role that mitochondria play: they impart a unique trait to cancer cells that can be exploited for cancer therapy"
Dario Alteri
Director University of Massachusetts Cancer Center
Research in immunology ~Wikipedia~
Many research reports consistently found that DCA was concentrated in the vicinity of tumors and inflammations. In conservative viewpoint, there was carcinogenicity suspected from DCA, but causality has not been demonstrated. The opinion of naturopaths and newer medical science is different.
In China, the traditional medicine "Niuhuang", which in Chinese means "Oxen Yellow" and is actually bilestone of oxen, has been in use for two millennia for the treatment of inflammations as well as to enhance the immune system. One of its main components is DCA.
Some European publications point towards the effect of DCA as an immunostimulant of the unspecific immune system, activating its main actors, the macrophages. According to these publications, a sufficient amount of DCA in the human body would correspond with a good immune reaction of the unspecific immune system. Clinical studies conducted in the 1970s and 1980s confirm the expectation, that DCA is involved in the natural healing processes of local inflammations, different types of herpes, and possibly cancer.
Applications
Deoxycholic acid has been used since its discovery in various fields of human medicine. In the human body deoxycholic acid is used in the emulsification of fats for the absorption in the intestine. It has, in some countries (including Switzerland) been licensed as an emulsifier in food industry, but it is no longer common. Outside the body it is used in experimental basis of cholagogues and is also in use to prevent and dissolve gallstones.
Sodium deoxycholate, the sodium salt of deoxycholic acid, is frequently used in mesotherapy injections, mixed with phosphatidylcholine.
In research deoxycholic acid is used as a mild detergent for the isolation of membrane associated proteins. The critical micelle concentration for deoxycholic acid is approximately 2.4-4 mM.
Sodium deoxycholate, the sodium salt of deoxycholic acid, is often used as a biological detergent to lyse cells and solubilise cellular and membrane components.
Deoxycholates and bile acid derivatives in general are actively being studied as structures for incorporation in nanotechnology. They also have found application in microlithography as photoresistant components.
Investing in Research
The DCA compound is not patented and not owned by any pharmaceutical company, and, therefore, would likely be an inexpensive drug to administer, says Michelakis, the Canada Research Chair in Pulmonary Hypertension and Director of the Pulmonary Hypertension Program with Capital Health, one of Canada's largest health authorities.
However, as DCA is not patented, Michelakis is concerned that it may be difficult to find funding from private investors to test DCA in clinical trials. He is grateful for the support he has already received from publicly funded agencies, such as the Canadian Institutes for Health Research (CIHR), and he is hopeful such support will continue and allow him to conduct clinical trials of DCA on cancer patients.
Michelakis' research is currently funded by the CIHR, the Canada Foundation for Innovation, the Canada Research Chairs program, and the Alberta Heritage Foundation for Medical Research.
"This preliminary research is encouraging and offers hope to thousands of Canadians and all others around the world who are afflicted by cancer, as it accelerates our understanding of and action around targeted cancer treatments," said Dr. Philip Branton, Scientific Director of the CIHR Institute of Cancer.
DCA and Cancer Patients
The University of Alberta's DCA Research Team is set to launch clinical trials on humans in the spring of 2007 pending government approval. Knowing that thousands of cancer patients die weekly while waiting for a cure, Dr. Michelakis and his team are working at accelerated speed, condensing research that usually takes years into months. Fundraisers at the University of Alberta are determined to raise the money to allow this next phase of research to begin. Once Health Canada grants formal approval, the University of Alberta's Research Team will begin testing DCA on patients living with cancer. Results with regards to the safety and efficacy of treatment should be known late this year.
"If there were a magic bullet, though, it might be something like dichloroacetate, or DCA..."
Newsweek, January 23, 2007
Cancer Cured in Canada, But Big Pharma Says NO WAY!
DCA Possible Cure for Cancer
RevolutionNewz | March 11, 2010 http://RevolutionNews.US - Rick Simpson. I have been providing people with Hemp Oil medicines, at no cost, for about three years. The results have been nothing short of amazing. Throughout man's history hemp has always been known as the most medicinal plant in the world. Even with this knowledge, hemp has always been used as a political and religious football.
I want this knowledge out there for everyone to learn! Watch the documentary Run From The Cure to understand more about using cannabis as a cure for cancer and other medical problems!
The current restrictions against hemp were put in place and maintained, not because hemp is evil or harmful, but for big money to make more big money, while we suffer and die needlessly. Look at a proposal such as this; if we were allowed to grow hemp in our back yards and cure our own illnesses, what do you think the reaction of the pharmaceutical industry would be to such a plan?
Many large pharmaceutical companies that still exist today sold hemp based medicines in the 1800's and early 1900's. They knew then what I have recently found out. Hemp oil if produced properly is a cure-all that the pharmaceutical industry can't patent.
To learn more about my and hemp oil, visit http://PhoenixTears.ca and watch the documentary Run From The Cure. Below the posted videos you will find more studies and research about cannabis curing cancer!
The current restrictions against hemp were put in place and maintained, not because hemp is evil or harmful, but for big money to make more big money, while we suffer and die needlessly. Look at a proposal such as this; if we were allowed to grow hemp in our back yards and cure our own illnesses, what do you think the reaction of the pharmaceutical industry would be to such a plan?
Many large pharmaceutical companies that still exist today sold hemp based medicines in the 1800's and early 1900's. They knew then what I have recently found out. Hemp oil if produced properly is a cure-all that the pharmaceutical industry can't patent.
To learn more about my and hemp oil, visit http://PhoenixTears.ca and watch the documentary Run From The Cure. Below the posted videos you will find more studies and research about cannabis curing cancer!
Breaking News: Cannabis Cures Cancer! 3/12/10
Daily News @ http://RevolutionNews.US ~ Researchers at Harvard tested the chemical THC in both lab and mouse studies. They say this is the first set of experiments to show that the compound, THC actually activates naturally produced receptors to fight off lung cancer. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.
Although a medical substitute of THC, known as Marinol, has been used as an appetite stimulant for cancer patients and other similar treatments, few studies have shown that THC might have anti-tumor activity.
*HERE IS THE INTERESTING PART* The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study. For three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression.
THC (marijuana) Helps Cure Cancer Says Harvard Study
Daily News @ http://RevolutionNews.US ~ Researchers at Harvard tested the chemical THC in both lab and mouse studies. They say this is the first set of experiments to show that the compound, THC actually activates naturally produced receptors to fight off lung cancer. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.
Although a medical substitute of THC, known as Marinol, has been used as an appetite stimulant for cancer patients and other similar treatments, few studies have shown that THC might have anti-tumor activity.
*HERE IS THE INTERESTING PART* The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study. For three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression.
THC (marijuana) Helps Cure Cancer Says Harvard Study
Mahendra Kumar Trivedi
Vibrating With Universal Consciousness
Applications of the New Phenomena
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